Telomere maintenance is one of the mechanisms ensuring indefinite divisions of cancer and stem cells.Good understanding of telomere maintenance mechanisms (TMM) is important for studying cancers and designing therapies.However, molecular factors triggering selective activation of either the telomerase dependent (TEL) or the alternative lengthening
Oxygen is essential to all the aerobic organisms.However, during normal development, disease and homeostasis, organisms are often challenged by hypoxia (oxygen deprivation).Hypoxia-inducible transcription factors (HIFs) are master dl0211 regulators of hypoxia response and are evolutionarily conserved in metazoans.The homolog of HIF in the genetic m
Brown adipose tissue (BAT) is known to be responsible for heat production in newborn and adult hibernating mammals.In rats and mice, BAT has been demonstrated to possess a much higher glycerokinase activity than white adipose tissue (WAT).It has been speculated that this high 2649-20 activity may cause the futile cycle of triglyceride breakdown and
The paper explores a subject that is getting more and more popular, namely how companies useloopholes to report domestic profits as being earned by subsidiaries in a tax haven, with the purposeto avoid paying taxes.I have chosen to present the case of the largest tech company in medline k4 basic wheelchair theworld: Apple Inc.Apple Inc., for two su
Purpose: this article includes the review of the Japanese policy on the digital transformation transformation of the agricultural sector, description and analysis of the implementation cases, as well as identification of obstacles to achieve the expected results.Methods: the study uses the methods of structural, comparative and systems analysis and